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Grape Seed

Grape seed extract (synonymous with “proanthocyanidins”) refer to procyanidin mixtures extracted from grape seeds. Proanthocyanidins—also called "OPCs" for oligomeric procyanidins or "PCOs" for procyanidolic oligomers—are a class of nutrients belonging to the flavonoid family.

Procyanidins are widely distributed in the plant kingdom and, in addition to being found in grape seeds, they are found in cocoa and chocolate, apples, peanuts, almonds, cranberries, blueberries and in the bark of pines, among other plant sources. Nutritional supplements containing proanthocyanidins extracts from various plant sources are available, alone or in combination with other nutrients, in herbal extracts, capsules, and tablets. Notwithstanding, grape seed extract is one of the most common source of procyanidins.

Proanthocyanidins are potent antioxidants and that play an important role in the stabilization of collagen and maintenance of elastin—two critical proteins in connective tissue that support joints, organs, muscle and blood vessels.

Flavonoids (proanthocyanidins and others) are a significant source of antioxidants in the average diet. Proanthocyanidins at 50–100 mg per day is considered a reasonable supplemental level by some doctors, but optimal levels remain unknown.


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