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Oxidation Reaction Theory of Aging
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Oxidation reactions occur when life essential oxygen combusts within the human body and produces by-products referred to as oxygen free radicals. When an oxidation reaction occurs in metals such as iron, everyone is aware that "rusting" occurs. When this same process occurs in people, it is called aging.
Free radicals produced by oxidation reactions are incomplete molecules that have lost an electron. When an oxygen molecule loses an electron, it is called singlet oxygen because only one of its electrons remains. Oxygen in this state is not stable. In an attempt restore balance, the free radical tries to steal an electron away from a nearby molecule, or donate its remaining electron to a nearby molecule. In doing so, the radical creates molecular instability that damages, disrupts, and even destroys nearby cells. If DNA is involved, the problem intensifies and genetic cell mutations may occur (a theory for the common cause of cancer). Uninhibited over time, free radical damage builds in the body, thus causing aging.
Free radicals are not only produced inside our bodies, but free radicals are also ingested through smoking, eating certain foods, water and air pollution, x-rays, extended exposure to the sun and a variety of other poisons we are exposed to in our every day environment.
E.R. Stadtman, a NIH researcher on aging, explains: "Aging is a disease. The human life span simply reflects the level of free radical oxidative damage that accumulates in cells. When enough damage accumulates, cells can't survive properly anymore and they just give up."
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The Oxidation Reaction Theory of Aging
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NIH researcher on aging
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